Hello. I have to chime in here. I am on anti-depressants as well. I would never ever recommend you just go off your meds cold turkey! Do not listen to people who will tell you this. Also, yes, talk to your Doctor, but your Doctor will give you the standard answer. May I ask you which med you are on, because a 50 pound weight gain sounds like a lot even for being on an anti-depressant. Usually when you first start taking an anti-depressant it has the effect of suppressing hunger and you will lose. 6 weeks is just about the point where these drugs kick in full gear. Please, talk to your Doc. and do not just quit!!!