Glutathione: Is More Better?

By Joel Brind, Ph.D. The subject of glutathione (GSH) came up in my last post on diet and inflammation, some of the comments reflecting the popularity of GSH as some sort of miracle molecule among alternative health purveyors and practitioners. Among the commenters, Sarah said: “Is this total BS? Is glutathione really the miracle substance some alternative med doctors say that it...

Glycine and Cancer

Comment from Martin Tornberg: “One thing that gives me pause with respect to consuming too much glycine is the study on?http://www.sciencemag.org/content/336/6084/1040.abstract?that ?identified glycine consumption and expression of the mitochondrial glycine biosynthetic pathway as strongly correlated with rates of proliferation across cancer cells? and noted that ?Antagonizing glycine...

Diet and Inflammation Part 4

By Joel Brind, Ph.D. My last post focused on the propagation of the inflammatory signal, and how nutrients such as omega-6 PUFAs and the lack of salicylic acid results in amplification of that signal, thus contributing to the overall increase in inflammation-related disease we currently experience. But what about the initiation of the inflammatory signal in the first place? That often turns out...

Diet and Inflammation Part 3

In my last post?Part 2 of this diet and inflammation series?I discussed the cells?called macrophages?which actually affect the inflammatory response, and how the amino acid glycine is crucial in regulating the activation of the macrophages at the level of the cell surface membrane. In the present installment, I’ll be discussing the propagation and amplification of the inflammatory...

Diet and Inflammation Part 2

My last post?part 1 of Diet and Inflammation?left off with my conclusion that the answer to the widespread prevalence of chronic inflammation was a nutritional imbalance incurred by the typical Western diet, specifically deficiencies or imbalances in 3 key nutrients: omega-3 (v. omega 6) fatty acids, salicylic acid and glycine (v. methionine). What exactly happens in inflammation? Inflammation...